JPET #204933 1 Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4
نویسندگان
چکیده
Department of Internal Medicine (L.G., S.B., J.Z., D.V.A., C.J.M.) and Department of Pharmacology & Toxicology (S.B., D.V.A., C.J.M.), Department of Surgery University of Louisville Medical Center (Y.L.), VA Medical Center (C.J.M.), UofL Alcohol Research Center, Louisville, Kentucky (L.G., S.B., J.Z., D.V.A., C.J.M.), Department of Medicine II, Section Molecular Hepatology Alcohol Associated Diseases, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (K.B-H., S.D.) JPET Fast Forward. Published on July 25, 2013 as DOI:10.1124/jpet.113.204933
منابع مشابه
Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.
Anti-inflammatory and antifibrotic effects of the broad spectrum phosphodiesterase (PDE) inhibitor pentoxifylline have suggested an important role for cyclic nucleotides in the pathogenesis of hepatic fibrosis; however, studies examining the role of specific PDEs are lacking. Endotoxemia and Toll-like receptor 4 (TLR4)-mediated inflammatory and profibrotic signaling play a major role in the dev...
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